DAG1 polyclonal antibody
产品名称： DAG1 polyclonal antibody
英文名称： DAG1 polyclonal antibody
产品编号： PAB18550
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of DAG1.
- Immunogen:
- A synthetic peptide corresponding to amino acids at internal region of human DAG1.
- Sequence:
- C-HVGKHEYFMHATDK
- Host:
- Goat
- Theoretical MW (kDa):
- 100
- Reactivity:
- Human
- Specificity:
- Reported variants represent identical protein: NP_001159400.1, NP_004384.3.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:128000)
Western Blot (0.2-0.6 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 1605
- Protein Accession#:
- NP_004384.3
- Gene Name:
- DAG1
- Gene Alias:
- 156DAG,A3a,AGRNR,DAG
- Gene Description:
- dystroglycan 1 (dystrophin-associated glycoprotein 1)
- Omim ID:
- 128239
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants
- Other Designations:
- alpha-dystroglycan,beta-dystroglycan,dystroglycan 1,dystrophin-associated glycoprotein-1